ezh2 inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2079	GSK126	GSK2816126A,EZH2 inhibitor	Histone Methyltransferase
	GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).		Histone Methyltransferase
T6484	EI1	KB-145943,Ezh2 inhibitor	Apoptosis , Histone Methyltransferase
	EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.		Apoptosis , Histone Methyltransferase
T7305	JQEZ5		Histone Methyltransferase
	JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).		Histone Methyltransferase
T25400	EZH2-IN-3	EZH2 inhibitor 3,EZH2-inhibitor-3
	EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.
T12428L	PF-06726304		Histone Methyltransferase
	PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).		Histone Methyltransferase
T1788	Tazemetostat	E-7438,EPZ6438	Histone Methyltransferase
	Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epith...		Histone Methyltransferase
T17002	Tazemetostat hydrobromide	E-7438 hydrobromide,EPZ-6438 hydrobromide	Histone Methyltransferase
	Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 n...		Histone Methyltransferase
T9700	EZH2-IN-2		Histone Methyltransferase
	EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM.		Histone Methyltransferase
T64043	EZH2-IN-13		Histone Methyltransferase
	EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.		Histone Methyltransferase
T2435	EPZ011989		Histone Methyltransferase
	EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.		Histone Methyltransferase
T6809	CPI-169 racemate	CPI 169,CPI-169,CPI169	Epigenetic Reader Domain , Histone Methyltransferase
	CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.		Epigenetic Reader Domain , Histone Methyltransferase
T1775	GSK503		Histone Methyltransferase
	GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.		Histone Methyltransferase
T12430	PF-06821497		Histone Methyltransferase
	PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.		Histone Methyltransferase
T1905	EPZ005687		Histone Methyltransferase
	EPZ005687 is a potent and selective inhibitor of EZH2.		Histone Methyltransferase
T67883	EZH2-IN-15	SHR2554	Histone Methyltransferase
	EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls the adaptive response via regulation of Treg activity. Intrat...		Histone Methyltransferase
T6810	CPI-360	Synonym 2,CPI 360,CPI360	Apoptosis , Histone Methyltransferase
	CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.		Apoptosis , Histone Methyltransferase
T3057	UNC1999		Histone Methyltransferase , Autophagy
	UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).		Histone Methyltransferase , Autophagy
T15194	EBI-2511		Histone Methyltransferase
	EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).		Histone Methyltransferase
T8201	Gambogenic acid		Histone Methyltransferase
	Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.		Histone Methyltransferase
T6059	GSK343		Histone Methyltransferase , Autophagy
	GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases.		Histone Methyltransferase , Autophagy